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Synthetic Drug Tusi Spreads Across the Globe, Causing Health Concerns
Crime By Michael A.G. · Nov 9, 2026

Synthetic Drug Tusi Spreads Across the Globe, Causing Health Concerns

The synthetic drug tusi, often marketed as a party drug and known by various names like "tusibi" or "2C," has gained significant popularity in recent years, particularly among young people at nightclubs. However, its widespread use masks a dangerous reality: users rarely know what they are actually ingesting due to the unpredictable nature of tusi's composition. According to Colombian and U.S. authorities, tusi is primarily sold as a recreational substance but has been linked to severe health issues such as vascular damage, poisonings, and even amputations.

Tusi originated in Europe during the late 2000s before making its way into Latin American nightclubs. It was initially based on 2C-B, a chemically engineered compound that produces effects similar to MDMA and LSD. However, due to the complexities of trafficking chemical precursors from Western Europe to South America, vendors began cutting it with cheaper substances like caffeine, ketamine, and other available powders. Over time, genuine 2C-B has been phased out entirely, replaced by a cocktail of various drugs mixed in kitchen settings.

Public health officials in Medellín have reported that tusi batches can contain up to nine different substances, while research from the Colombian harm reduction group Echele Cabeza indicates as many as 18 compounds appearing across samples. These mixtures often combine depressants and stimulants, increasing the risk of overdose. Lab tests reveal that ketamine is typically a primary ingredient in tusi, along with MDMA, methamphetamine, and other stimulants. Some batches also test positive for synthetic cathinones (bath salts), fentanyl, and other opioids, posing significant health risks to users who may not be aware of the opioid content.

The inconsistent composition of tusi makes it challenging for law enforcement agencies to track down specific manufacturers or distributors. Traffickers continuously adapt their methods based on regional drug availability, further complicating efforts to regulate its production and distribution. Despite these challenges, tusi has become known as "pink cocaine" in many circles due to its appearance and marketing tactics.

The evolving nature of tusi highlights the ongoing struggle between law enforcement and criminal organizations in combating synthetic drug trafficking. As users continue to seek out new substances for recreational use, public health officials warn that the dangers associated with unknown drug compositions pose a significant threat to public safety.

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